Nature Communications (Oct 2021)
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models
- Pauline Maisonnasse,
- Yoann Aldon,
- Aurélien Marc,
- Romain Marlin,
- Nathalie Dereuddre-Bosquet,
- Natalia A. Kuzmina,
- Alec W. Freyn,
- Jonne L. Snitselaar,
- Antonio Gonçalves,
- Tom G. Caniels,
- Judith A. Burger,
- Meliawati Poniman,
- Ilja Bontjer,
- Virginie Chesnais,
- Ségolène Diry,
- Anton Iershov,
- Adam J. Ronk,
- Sonia Jangra,
- Raveen Rathnasinghe,
- Philip J. M. Brouwer,
- Tom P. L. Bijl,
- Jelle van Schooten,
- Mitch Brinkkemper,
- Hejun Liu,
- Meng Yuan,
- Chad E. Mire,
- Mariëlle J. van Breemen,
- Vanessa Contreras,
- Thibaut Naninck,
- Julien Lemaître,
- Nidhal Kahlaoui,
- Francis Relouzat,
- Catherine Chapon,
- Raphaël Ho Tsong Fang,
- Charlene McDanal,
- Mary Osei-Twum,
- Natalie St-Amant,
- Luc Gagnon,
- David C. Montefiori,
- Ian A. Wilson,
- Eric Ginoux,
- Godelieve J. de Bree,
- Adolfo García-Sastre,
- Michael Schotsaert,
- Lynda Coughlan,
- Alexander Bukreyev,
- Sylvie van der Werf,
- Jérémie Guedj,
- Rogier W. Sanders,
- Marit J. van Gils,
- Roger Le Grand
Affiliations
- Pauline Maisonnasse
- Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre
- Yoann Aldon
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Aurélien Marc
- Université de Paris, INSERM, IAME
- Romain Marlin
- Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre
- Nathalie Dereuddre-Bosquet
- Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre
- Natalia A. Kuzmina
- Department of Pathology, University of Texas Medical Branch at Galveston
- Alec W. Freyn
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Jonne L. Snitselaar
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Antonio Gonçalves
- Université de Paris, INSERM, IAME
- Tom G. Caniels
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Judith A. Burger
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Meliawati Poniman
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Ilja Bontjer
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Virginie Chesnais
- Life and Soft
- Ségolène Diry
- Life and Soft
- Anton Iershov
- Life and Soft
- Adam J. Ronk
- Department of Pathology, University of Texas Medical Branch at Galveston
- Sonia Jangra
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Raveen Rathnasinghe
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Philip J. M. Brouwer
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Tom P. L. Bijl
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Jelle van Schooten
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Mitch Brinkkemper
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Hejun Liu
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Meng Yuan
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Chad E. Mire
- Galveston National Laboratory
- Mariëlle J. van Breemen
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Vanessa Contreras
- Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre
- Thibaut Naninck
- Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre
- Julien Lemaître
- Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre
- Nidhal Kahlaoui
- Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre
- Francis Relouzat
- Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre
- Catherine Chapon
- Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre
- Raphaël Ho Tsong Fang
- Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre
- Charlene McDanal
- Duke Human Vaccine Institute & Department of Surgery
- Mary Osei-Twum
- Nexelis, Laval
- Natalie St-Amant
- Nexelis, Laval
- Luc Gagnon
- Nexelis, Laval
- David C. Montefiori
- Duke Human Vaccine Institute & Department of Surgery
- Ian A. Wilson
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Eric Ginoux
- Life and Soft
- Godelieve J. de Bree
- Internal Medicine of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Adolfo García-Sastre
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Michael Schotsaert
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Lynda Coughlan
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Alexander Bukreyev
- Department of Pathology, University of Texas Medical Branch at Galveston
- Sylvie van der Werf
- Molecular Genetics of RNA Viruses, Department of Virology, Institut Pasteur, CNRS UMR 3569, Université de Paris
- Jérémie Guedj
- Université de Paris, INSERM, IAME
- Rogier W. Sanders
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Marit J. van Gils
- Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity
- Roger Le Grand
- Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre
- DOI
- https://doi.org/10.1038/s41467-021-26354-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Monoclonal antibodies show great promise in treating Covid-19 patients. Here, Maisonnasse, Aldon and colleagues report pre-clinical results for COVA1-18 and demonstrate that it reduces viral infectivity in three animal models with over 95% efficacy in macaques upper respiratory tract.
