TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand

Abstract

A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient’s T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which might contribute to COVID-19 severity.

Keywords

• COVID-19
• respiratory infections
• severe acute respiratory syndrome coronavirus 2
• SARS-CoV-2
• SARS
• coronavirus disease