Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury

Mildred C. Embree; Mo Chen; Serhiy Pylawka; Danielle Kong; George M. Iwaoka; Ivo Kalajzic; Hai Yao; Chancheng Shi; Dongming Sun; Tzong-Jen Sheu; David A. Koslovsky; Alia Koch; Jeremy J. Mao

doi:10.1038/ncomms13073

Nature Communications (Oct 2016)

Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury

Mildred C. Embree,
Mo Chen,
Serhiy Pylawka,
Danielle Kong,
George M. Iwaoka,
Ivo Kalajzic,
Hai Yao,
Chancheng Shi,
Dongming Sun,
Tzong-Jen Sheu,
David A. Koslovsky,
Alia Koch,
Jeremy J. Mao

Affiliations

Mildred C. Embree: TMJ Biology and Regenerative Medicine Laboratory, College of Dental Medicine, Columbia University Medical Center
Mo Chen: Center for Craniofacial Regeneration, College of Dental Medicine, Columbia University Medical Center
Serhiy Pylawka: TMJ Biology and Regenerative Medicine Laboratory, College of Dental Medicine, Columbia University Medical Center
Danielle Kong: Center for Craniofacial Regeneration, College of Dental Medicine, Columbia University Medical Center
George M. Iwaoka: Center for Craniofacial Regeneration, College of Dental Medicine, Columbia University Medical Center
Ivo Kalajzic: Department of Reconstructive Sciences, MC3705, L7005, University of Connecticut Health Sciences Center
Hai Yao: Department of Bioengineering, Clemson-MUSC Bioengineering Program, Clemson University
Chancheng Shi: Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences
Dongming Sun: W.M. Keck Center for Collaborative Neuroscience, Rutgers, The State University of New Jersey
Tzong-Jen Sheu: Center for Musculoskeletal Research, University of Rochester Medical Center
David A. Koslovsky: Metropolitan Oral Surgery Associates, 488 Madison Avenue, #200
Alia Koch: Division of Oral and Maxillofacial Surgery, College of Dental Medicine, Columbia University Medical Center
Jeremy J. Mao: Center for Craniofacial Regeneration, College of Dental Medicine, Columbia University Medical Center

DOI: https://doi.org/10.1038/ncomms13073
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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A potentially superior tissue regenerative strategy to stem cell transplantation is modulation of endogenous stem cells. Here the authors show fibrocartilage stem cells exist in the temporomandibular joint that contribute to cartilage regeneration and can be manipulated to enhance regeneration through canonical Wnt signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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