Nature Communications (Jun 2020)

Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage

  • Jinman Chen,
  • Linmei Wang,
  • Hao Xu,
  • Lianping Xing,
  • Zixin Zhuang,
  • Yangkang Zheng,
  • Xuefei Li,
  • Chinyun Wang,
  • Shaohua Chen,
  • Zibin Guo,
  • Qianqian Liang,
  • Yongjun Wang

DOI
https://doi.org/10.1038/s41467-020-16851-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Extravasated erythrocytes in cerebrospinal fluid (CSF) contribute to the pathogenesis of subarachnoid haemorrhage (SAH). Here, the authors show that meningeal lymphatics drain extravasated erythorcytes and that blockage of this drainage aggravates SAH severity.