Psoriasis: Targets and Therapy (Aug 2025)

Epidemiology of Hypertension in Psoriasis: An Analysis of Trends from 2006 to 2023

  • Zhang M,
  • Chen JL,
  • Fan SW,
  • Sun XY,
  • Zhou YQ,
  • Luo Y,
  • Wang J,
  • Wang CX,
  • Lin NX,
  • Liu L,
  • Li X

Journal volume & issue
Vol. Volume 15, no. Issue 1
pp. 443 – 453

Abstract

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Miao Zhang,1,2,* Jia-Le Chen,1,2,* Si-Wei Fan,2 Xiao-Ying Sun,2 Ya-Qiong Zhou,2 Ying Luo,2 Jiao Wang,1,2 Chun-Xiao Wang,1,2 Nai-Xuan Lin,1,2 Liu Liu,1,2 Xin Li1,2 1Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, People’s Republic of China; 2Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Li, Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai, 200437, People’s Republic of China, Tel +86 21 6516178-3424, Fax +86 21 65162629, Email [email protected] Liu Liu, Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai, 200437, People’s Republic of China, Tel +86 21 6516178-3424, Fax +86 21 65162629, Email [email protected]: Psoriasis and hypertension (HTN) are known to be closely related. However, at present, no study has systematically examined the epidemiology of this disease pattern on a global scale.Methods: We examined six databases from their inception until November 1, 2023 and used the Agency for Healthcare Research and Quality and the Newcastle-Ottawa Scale to assess the quality of observational studies. Data analysis was conducted in R. Meta-regression, sensitivity, and subgroup analyses were used to evaluate interstudy heterogeneity. Egger’s test and funnel plots were used to evaluate publication bias.Results: We reviewed 200 studies involving 15,010,888 patients. The overall prevalence of HTN among the patients with psoriasis was 32.22%. Overall, South America had the highest prevalence of hypertension among adult patients with psoriasis (52.36%), the three countries with the highest prevalence were Serbia, Singapore and Brazil. The prevalence of mild and severe psoriasis comorbid with HTN was 31.71% [95% CI: 24.40– 40.05%] and 33.19% [95% CI: 27.17– 39.81%], respectively. The prevalence of HTN in psoriasis vulgaris was 29.71% [95% CI: 25.10– 35.15%], while that in psoriatic arthritis was 34.54% [95% CI: 31.27– 38.14%].Conclusion: Patients with psoriatic arthritis are more predisposed to requiring hypertension risk screening than patients with psoriasis vulgaris. More population-based prospective observational studies are required to elucidate the mechanisms underlying the coexistence of hypertension in patients with psoriasis.Keywords: psoriasis, hypertension, epidemiology, comorbidity, prevalence

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