Nature Communications (Jul 2021)
Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection
- Zhe Zhao,
- Huimeng Wang,
- Mai Shi,
- Tianyuan Zhu,
- Troi Pediongco,
- Xin Yi Lim,
- Bronwyn S. Meehan,
- Adam G. Nelson,
- David P. Fairlie,
- Jeffrey Y. W. Mak,
- Sidonia B. G. Eckle,
- Marcela de Lima Moreira,
- Carolin Tumpach,
- Michael Bramhall,
- Cameron G. Williams,
- Hyun Jae Lee,
- Ashraful Haque,
- Maximilien Evrard,
- Jamie Rossjohn,
- James McCluskey,
- Alexandra J. Corbett,
- Zhenjun Chen
Affiliations
- Zhe Zhao
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Huimeng Wang
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Mai Shi
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Tianyuan Zhu
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Troi Pediongco
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Xin Yi Lim
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Bronwyn S. Meehan
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Adam G. Nelson
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- David P. Fairlie
- Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland
- Jeffrey Y. W. Mak
- Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland
- Sidonia B. G. Eckle
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Marcela de Lima Moreira
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Carolin Tumpach
- Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Michael Bramhall
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Cameron G. Williams
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Hyun Jae Lee
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Ashraful Haque
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Maximilien Evrard
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Jamie Rossjohn
- Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- James McCluskey
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Alexandra J. Corbett
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Zhenjun Chen
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- DOI
- https://doi.org/10.1038/s41467-021-24570-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Mucosal-Associated Invariant T (MAIT) cells are associated with established functions during bacterial infection. Here the authors show inoculation with Francisella tularensis results in induction of MAIT cells associated with prototypic Th1 immunity and confer protection to systemic and local infection.
