Effects of stocking density on the homeostasis of uric acid and related liver and kidney functions in ducks

Peiyi Lin; Sui Liufu; Jinhui Wang; Zhanpeng Hou; Yu Liang; Haiyue Wang; Bingxin Li; Nan Cao; Wenjun Liu; Yunmao Huang; Yunbo Tian; Danning Xu; Xiujin Li; Xinliang Fu

doi:10.5713/ab.23.0364

Animal Bioscience (May 2024)

Effects of stocking density on the homeostasis of uric acid and related liver and kidney functions in ducks

Peiyi Lin,
Sui Liufu,
Jinhui Wang,
Zhanpeng Hou,
Yu Liang,
Haiyue Wang,
Bingxin Li,
Nan Cao,
Wenjun Liu,
Yunmao Huang,
Yunbo Tian,
Danning Xu,
Xiujin Li,
Xinliang Fu

Affiliations

Peiyi Lin: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Sui Liufu: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Jinhui Wang: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Zhanpeng Hou: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Yu Liang: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Haiyue Wang: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Bingxin Li: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Nan Cao: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Wenjun Liu: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Yunmao Huang: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Yunbo Tian: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Danning Xu: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Xiujin Li: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Xinliang Fu: College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China

DOI: https://doi.org/10.5713/ab.23.0364
Journal volume & issue: Vol. 37, no. 5
pp. 952 – 961

Abstract

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Objective Stocking density (SD) is an important issue in the poultry industry, which is related to the production performance, intestinal health and immune status. In the present study, the effects of SD on the metabolism and homeostasis of uric acid as well as the related functions of the liver and kidney in ducks were examined. Methods A total of 360 healthy 56-day-old Shan-ma ducks were randomly divided into the low stocking density (n = 60, density = 5 birds/m2), medium stocking density (n = 120, density = 10 birds/m2) and high stocking density groups (HSD; n = 180, density = 15 birds/m2). Samples were collected in the 3rd, 6th, and 9th weeks of the experiment for analysis. Results The serum levels of uric acid, lipopolysaccharide and inflammatory cytokines (interleukin-1β [IL-1β], IL-8, and tumor necrosis factor-α [TNF-α]) were increased significantly in the HSD group. Serious histopathological lesions could be seen in both the livers and kidneys in the HSD group in the 9th week. The mRNA expression levels of inflammatory cytokines (IL-8 and TNF-α) and related pathway components (toll-like receptor 4, myeloid differentiation primary response gene 88, and nuclear factor-κB) were increased significantly in both the livers and kidneys in the HSD group. The mRNA expression levels of enzymes (adenosine deaminase, xanthine oxidase, phosphoribosyl pyrophosphate amidotransferase, and phosphoribosyl pyrophosphate synthetase 1) related to the synthesis of uric acid increased significantly in the livers in the HSD group. However, the mRNA expression level of solute carrier family 2 member 9, which plays an important role in the excretion of uric acid by the kidney, was decreased significantly in the kidneys in the HSD group. Conclusion These results indicated that a higher SD could cause tissue inflammatory lesions in the liver and kidney and subsequently affect the metabolism and homeostasis of uric acid, and is helpful for guiding decisions related to the breeding and production of ducks.

Published in Animal Bioscience

ISSN: 2765-0189 (Print); 2765-0235 (Online)
Publisher: Asian-Australasian Association of Animal Production Societies
Country of publisher: Korea, Republic of
LCC subjects: Science: Zoology
Website: https://www.animbiosci.org/index.php

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