Nature Communications (Sep 2022)
Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling
- Yusuke Adachi,
- Kazutaka Ueda,
- Seitaro Nomura,
- Kaoru Ito,
- Manami Katoh,
- Mikako Katagiri,
- Shintaro Yamada,
- Masaki Hashimoto,
- Bowen Zhai,
- Genri Numata,
- Akira Otani,
- Munetoshi Hinata,
- Yuta Hiraike,
- Hironori Waki,
- Norifumi Takeda,
- Hiroyuki Morita,
- Tetsuo Ushiku,
- Toshimasa Yamauchi,
- Eiki Takimoto,
- Issei Komuro
Affiliations
- Yusuke Adachi
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Kazutaka Ueda
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Seitaro Nomura
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Kaoru Ito
- Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences
- Manami Katoh
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Mikako Katagiri
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Shintaro Yamada
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Masaki Hashimoto
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Bowen Zhai
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Genri Numata
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Akira Otani
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Munetoshi Hinata
- Department of Pathology, Graduate School of Medicine, The University of Tokyo
- Yuta Hiraike
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Hironori Waki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Norifumi Takeda
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Hiroyuki Morita
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Tetsuo Ushiku
- Department of Pathology, Graduate School of Medicine, The University of Tokyo
- Toshimasa Yamauchi
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Eiki Takimoto
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Issei Komuro
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-022-32658-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Perivascular adipose tissue (PVAT) has been reported to undergo inflammatory changes in response to vascular injury. Here, the authors show that vascular injury induces the beiging (brown adipose tissue-like phenotype change) of PVAT, which fine-tunes inflammatory response as a protective mechanism.
