Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin B

Abstract

Fate determination and maintenance of foetal testes in most animals occurs cell autonomously. Here the authors show in mouse XY embryos that Sertoli cell derived AMH and activin B together maintain Sertoli cell identity, and lack of both AMH and activin B leads to transdifferentiation into female granulosa cells.