Haematologica (Sep 2016)
Clinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations
- Takeshi Ryotokuji,
- Hiroki Yamaguchi,
- Toshimitsu Ueki,
- Kensuke Usuki,
- Saiko Kurosawa,
- Yutaka Kobayashi,
- Eri Kawata,
- Kenji Tajika,
- Seiji Gomi,
- Junya Kanda,
- Anna Kobayashi,
- Ikuko Omori,
- Atsushi Marumo,
- Yusuke Fujiwara,
- Shunsuke Yui,
- Kazuki Terada,
- Keiko Fukunaga,
- Tsuneaki Hirakawa,
- Kunihito Arai,
- Tomoaki Kitano,
- Fumiko Kosaka,
- Hayato Tamai,
- Kazutaka Nakayama,
- Satoshi Wakita,
- Takahiro Fukuda,
- Koiti Inokuchi
Affiliations
- Takeshi Ryotokuji
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Hiroki Yamaguchi
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Toshimitsu Ueki
- Department of Hematology, Nagano Red Cross Hospital, Tokyo, Japan
- Kensuke Usuki
- Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
- Saiko Kurosawa
- Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
- Yutaka Kobayashi
- Department of Hematology, Japanese Red Cross Kyoto Daini Hospital, Japan
- Eri Kawata
- Department of Hematology, Japanese Red Cross Kyoto Daini Hospital, Japan
- Kenji Tajika
- Department of Hematology, Yokohama Minami Kyousai Hospital, Kanagawa, Japan
- Seiji Gomi
- Department of Hematology, Yokohama Minami Kyousai Hospital, Kanagawa, Japan
- Junya Kanda
- Division of Hematology, Saitama Medical Center Jichi Medical University, Japan
- Anna Kobayashi
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Ikuko Omori
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Atsushi Marumo
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Yusuke Fujiwara
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Shunsuke Yui
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Kazuki Terada
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Keiko Fukunaga
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Tsuneaki Hirakawa
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Kunihito Arai
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Tomoaki Kitano
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Fumiko Kosaka
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Hayato Tamai
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Kazutaka Nakayama
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Satoshi Wakita
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- Takahiro Fukuda
- Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
- Koiti Inokuchi
- Department of Hematology, Nippon Medical School, Tokyo, Japan
- DOI
- https://doi.org/10.3324/haematol.2016.143073
- Journal volume & issue
-
Vol. 101,
no. 9
Abstract
In recent years, it has been reported that the frequency of DNA-methylation regulatory gene mutations – mutations of the genes that regulate gene expression through DNA methylation – is high in acute myeloid leukemia. The objective of the present study was to elucidate the clinical characteristics and prognosis of acute myeloid leukemia with associated DNA-methylation regulatory gene mutation. We studied 308 patients with acute myeloid leukemia. DNA-methylation regulatory gene mutations were observed in 135 of the 308 cases (43.8%). Acute myeloid leukemia associated with a DNA-methylation regulatory gene mutation was more frequent in older patients (P
