Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients
Adequate Mhlanga,
Rami Zakh,
Alexander Churkin,
Vladimir Reinharz,
Jeffrey S. Glenn,
Ohad Etzion,
Scott J. Cotler,
Cihan Yurdaydin,
Danny Barash,
Harel Dahari
Affiliations
Adequate Mhlanga
The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA
Rami Zakh
Department of Computer Science, Ben-Gurion University, Beer-Sheva 84105, Israel
Alexander Churkin
Department of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 84108, Israel
Vladimir Reinharz
Department of Computer Science, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada
Jeffrey S. Glenn
Division of Gastroenterology and Hepatology, Departments of Medicine, Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA
Ohad Etzion
Department of Gastroenterology and Liver Diseases, Soroka University Medical Center, Beer-Sheva 84101, Israel
Scott J. Cotler
The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA
Cihan Yurdaydin
Department of Gastroenterology and Hepatology, Koç University Medical School, Istanbul 34450, Turkey
Danny Barash
Department of Computer Science, Ben-Gurion University, Beer-Sheva 84105, Israel
Harel Dahari
The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA
Hepatitis D virus is an infectious subviral agent that can only propagate in people infected with hepatitis B virus. In this study, we modified and further developed a recent model for early hepatitis D virus and hepatitis B virus kinetics to better reproduce hepatitis D virus and hepatitis B virus kinetics measured in infected patients during anti-hepatitis D virus treatment. The analytical solutions were provided to highlight the new features of the modified model. The improved model offered significantly better prospects for modeling hepatitis D virus and hepatitis B virus interactions.
