Analysis of polygenic risk score usage and performance in diverse human populations

L. Duncan; H. Shen; B. Gelaye; J. Meijsen; K. Ressler; M. Feldman; R. Peterson; B. Domingue

doi:10.1038/s41467-019-11112-0

Nature Communications (Jul 2019)

Analysis of polygenic risk score usage and performance in diverse human populations

L. Duncan,
H. Shen,
B. Gelaye,
J. Meijsen,
K. Ressler,
M. Feldman,
R. Peterson,
B. Domingue

Affiliations

L. Duncan: Department of Psychiatry and Behavioral Sciences, Stanford University
H. Shen: Department of Psychiatry and Behavioral Sciences, Stanford University
B. Gelaye: Department of Epidemiology, Harvard T.H. Chan School of Public Health
J. Meijsen: Department of Psychiatry and Behavioral Sciences, Stanford University
K. Ressler: Mailman Research Center, Harvard Medical School, McLean Hospital
M. Feldman: Department of Biology, Stanford University
R. Peterson: Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University
B. Domingue: Graduate School of Education, CERAS 510, Stanford University

DOI: https://doi.org/10.1038/s41467-019-11112-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

Predominant participation of European-ancestry individuals in genetic studies has hindered the better understanding of genetic risk in non-European ancestry individuals. Here, Duncan et al. quantify polygenic risk score use and performance in worldwide populations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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