Nature Communications (Jun 2020)
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
- Andrea Strakova,
- Thomas J. Nicholls,
- Adrian Baez-Ortega,
- Máire Ní Leathlobhair,
- Alexander T. Sampson,
- Katherine Hughes,
- Isobelle A. G. Bolton,
- Kevin Gori,
- Jinhong Wang,
- Ilona Airikkala-Otter,
- Janice L. Allen,
- Karen M. Allum,
- Clara L. Arnold,
- Leontine Bansse-Issa,
- Thinlay N. Bhutia,
- Jocelyn L. Bisson,
- Kelli Blank,
- Cristóbal Briceño,
- Artemio Castillo Domracheva,
- Anne M. Corrigan,
- Hugh R. Cran,
- Jane T. Crawford,
- Stephen M. Cutter,
- Eric Davis,
- Karina F. de Castro,
- Andrigo B. De Nardi,
- Anna P. de Vos,
- Laura Delgadillo Keenan,
- Edward M. Donelan,
- Adela R. Espinoza Huerta,
- Ibikunle A. Faramade,
- Mohammed Fazil,
- Eleni Fotopoulou,
- Skye N. Fruean,
- Fanny Gallardo-Arrieta,
- Olga Glebova,
- Pagona G. Gouletsou,
- Rodrigo F. Häfelin Manrique,
- Joaquim J. G. P. Henriques,
- Rodrigo S. Horta,
- Natalia Ignatenko,
- Yaghouba Kane,
- Cathy King,
- Debbie Koenig,
- Ada Krupa,
- Steven J. Kruzeniski,
- Marta Lanza-Perea,
- Mihran Lazyan,
- Adriana M. Lopez Quintana,
- Thibault Losfelt,
- Gabriele Marino,
- Simón Martínez Castañeda,
- Mayra F. Martínez-López,
- Bedan M. Masuruli,
- Michael Meyer,
- Edward J. Migneco,
- Berna Nakanwagi,
- Karter B. Neal,
- Winifred Neunzig,
- Sally J. Nixon,
- Antonio Ortega-Pacheco,
- Francisco Pedraza-Ordoñez,
- Maria C. Peleteiro,
- Katherine Polak,
- Ruth J. Pye,
- Juan C. Ramirez-Ante,
- John F. Reece,
- Jose Rojas Gutierrez,
- Haleema Sadia,
- Sheila K. Schmeling,
- Olga Shamanova,
- Alan G. Sherlock,
- Audrey E. Steenland-Smit,
- Alla Svitich,
- Lester J. Tapia Martínez,
- Ismail Thoya Ngoka,
- Cristian G. Torres,
- Elizabeth M. Tudor,
- Mirjam G. van der Wel,
- Bogdan A. Vițălaru,
- Sevil A. Vural,
- Oliver Walkinton,
- Alvaro S. Wehrle-Martinez,
- Sophie A. E. Widdowson,
- Irina Zvarich,
- Patrick F. Chinnery,
- Maria Falkenberg,
- Claes M. Gustafsson,
- Elizabeth P. Murchison
Affiliations
- Andrea Strakova
- Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge
- Thomas J. Nicholls
- Department of Medical Biochemistry and Cell Biology, University of Gothenburg
- Adrian Baez-Ortega
- Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge
- Máire Ní Leathlobhair
- Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge
- Alexander T. Sampson
- Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge
- Katherine Hughes
- Department of Veterinary Medicine, University of Cambridge
- Isobelle A. G. Bolton
- Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge
- Kevin Gori
- Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge
- Jinhong Wang
- Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge
- Ilona Airikkala-Otter
- Worldwide Veterinary Service, International Training Center
- Janice L. Allen
- Animal Management in Rural and Remote Indigenous Communities (AMRRIC)
- Karen M. Allum
- World Vets
- Clara L. Arnold
- Hopkins Belize Humane Society
- Leontine Bansse-Issa
- Animal Shelter, Stichting Dierenbescherming Suriname
- Thinlay N. Bhutia
- Sikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim
- Jocelyn L. Bisson
- Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge
- Kelli Blank
- Hopkins Belize Humane Society
- Cristóbal Briceño
- ConserLab, Animal Preventive Medicine Department, Faculty of Animal and Veterinary Sciences, University of Chile
- Artemio Castillo Domracheva
- Corozal Veterinary Hospital, University of Panamá
- Anne M. Corrigan
- St. George’s University
- Hugh R. Cran
- The Nakuru District Veterinary Scheme Ltd
- Jane T. Crawford
- Animal Medical Centre
- Stephen M. Cutter
- Animal Management in Rural and Remote Indigenous Communities (AMRRIC)
- Eric Davis
- International Animal Welfare Training Institute, UC Davis School of Veterinary Medicine
- Karina F. de Castro
- Centro Universitário de Rio Preto (UNIRP), São José do Rio Preto
- Andrigo B. De Nardi
- School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP)
- Anna P. de Vos
- Ladybrand Animal Clinic
- Laura Delgadillo Keenan
- Veterinary Clinic Sr. Dog’s
- Edward M. Donelan
- Animal Management in Rural and Remote Indigenous Communities (AMRRIC)
- Adela R. Espinoza Huerta
- World Vets Latin America Veterinary Training Center
- Ibikunle A. Faramade
- National Veterinary Research Institute
- Mohammed Fazil
- Animal Clinic
- Eleni Fotopoulou
- Intermunicipal Stray Animals Care Centre (DIKEPAZ)
- Skye N. Fruean
- Animal Protection Society of Samoa
- Fanny Gallardo-Arrieta
- Faculty of Veterinary Science, University of Zulia
- Olga Glebova
- Veterinary Clinic BIOCONTROL
- Pagona G. Gouletsou
- Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly
- Rodrigo F. Häfelin Manrique
- Veterinary Clinic El Roble, Animal Healthcare Network, Faculty of Animal and Veterinary Sciences, University of Chile
- Joaquim J. G. P. Henriques
- OnevetGroup, Hospital Veterinário Berna
- Rodrigo S. Horta
- Universidade Vila Velha
- Natalia Ignatenko
- Veterinary Clinic Zoovetservis
- Yaghouba Kane
- École Inter-états des Sciences et Médecine Vétérinaires de Dakar
- Cathy King
- World Vets
- Debbie Koenig
- World Vets
- Ada Krupa
- Department of Small Animal Medicine, Faculty of Veterinary Medicine, Utrecht University
- Steven J. Kruzeniski
- World Vets Latin America Veterinary Training Center
- Marta Lanza-Perea
- St. George’s University
- Mihran Lazyan
- Vetexpert Veterinary Group
- Adriana M. Lopez Quintana
- Lopez Quintana Veterinary Clinic
- Thibault Losfelt
- Clinique Veterinaire de Grand Fond, Saint Gilles les Bains
- Gabriele Marino
- Department of Veterinary Sciences, University of Messina
- Simón Martínez Castañeda
- Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México
- Mayra F. Martínez-López
- School of Veterinary Medicine, Universidad de las Américas
- Bedan M. Masuruli
- Veterinary Council of Tanzania
- Michael Meyer
- Touray & Meyer Vet Clinic
- Edward J. Migneco
- Hillside Animal Hospital
- Berna Nakanwagi
- The Kampala Veterinary Surgery
- Karter B. Neal
- Asavet Veterinary Charities
- Winifred Neunzig
- World Vets
- Sally J. Nixon
- Vets Beyond Borders
- Antonio Ortega-Pacheco
- Faculty of Veterinary Medicine, Autonomous University of Yucatan
- Francisco Pedraza-Ordoñez
- Laboratorio de Patología Veterinaria, Universidad de Caldas
- Maria C. Peleteiro
- Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon
- Katherine Polak
- Four Paws International
- Ruth J. Pye
- Vets Beyond Borders
- Juan C. Ramirez-Ante
- Laboratorio de Patología Veterinaria, Universidad de Caldas
- John F. Reece
- Help in Suffering
- Jose Rojas Gutierrez
- Veterinary Clinic Dr José Rojas
- Haleema Sadia
- Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences
- Sheila K. Schmeling
- Corozal Veterinary Clinic
- Olga Shamanova
- Veterinary Clinic Vetmaster
- Alan G. Sherlock
- Vets Beyond Borders
- Audrey E. Steenland-Smit
- Animal Shelter, Stichting Dierenbescherming Suriname
- Alla Svitich
- State Hospital of Veterinary Medicine
- Lester J. Tapia Martínez
- World Vets Latin America Veterinary Training Center
- Ismail Thoya Ngoka
- Jomo Kenyatta University of Agriculture and Technology
- Cristian G. Torres
- Laboratory of Biomedicine and Regenerative Medicine, Department of Clinical Sciences, Faculty of Animal and Veterinary Sciences, University of Chile
- Elizabeth M. Tudor
- Faculty of Veterinary and Agricultural Sciences, University of Melbourne
- Mirjam G. van der Wel
- Animal Anti Cruelty League
- Bogdan A. Vițălaru
- Clinical Sciences Department, Faculty of Veterinary Medicine Bucharest
- Sevil A. Vural
- Department of Pathology, Faculty of Veterinary Medicine, Ankara University
- Oliver Walkinton
- Vets Beyond Borders
- Alvaro S. Wehrle-Martinez
- Faculty of Veterinary Sciences, National University of Asuncion
- Sophie A. E. Widdowson
- Lilongwe Society for Protection and Care of Animals (LSPCA)
- Irina Zvarich
- Veterinary clinic Canine Heart
- Patrick F. Chinnery
- MRC-Mitochondrial Biology Unit & Department of Clinical Neurosciences, University of Cambridge
- Maria Falkenberg
- Department of Medical Biochemistry and Cell Biology, University of Gothenburg
- Claes M. Gustafsson
- Department of Medical Biochemistry and Cell Biology, University of Gothenburg
- Elizabeth P. Murchison
- Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-020-16765-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The competitive dynamics of mitochondrial haplotypes juxtaposed within the same cell are poorly studied. Here the authors show, in the context of a transmissible cancer, that one haplotype has recurrently entered cancer cells by horizontal transfer and appears to have a ‘selfish’ selective advantage.
