Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

Chunbai He; Xiaopin Duan; Nining Guo; Christina Chan; Christopher Poon; Ralph R. Weichselbaum; Wenbin Lin

doi:10.1038/ncomms12499

Nature Communications (Aug 2016)

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

Chunbai He,
Xiaopin Duan,
Nining Guo,
Christina Chan,
Christopher Poon,
Ralph R. Weichselbaum,
Wenbin Lin

Affiliations

Chunbai He: Department of Chemistry, The University of Chicago
Xiaopin Duan: Department of Chemistry, The University of Chicago
Nining Guo: Department of Chemistry, The University of Chicago
Christina Chan: Department of Chemistry, The University of Chicago
Christopher Poon: Department of Chemistry, The University of Chicago
Ralph R. Weichselbaum: Department of Radiation and Cellular Oncology and The Ludwig Center for Metastasis Research, The University of Chicago
Wenbin Lin: Department of Chemistry, The University of Chicago

DOI: https://doi.org/10.1038/ncomms12499
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Blockade of PD-L1 is usually not very effective in colon cancer patients. Here, the authors show the efficacy of PD-L1 blockade in combination with coordination polymer nanoparticles carrying oxaliplatin and a photosensitizer to induce anti-tumor immunity in metastatic models of colon cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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