Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic leukemia

• Laurence C. Cheung,
• Mark N. Cruickshank,
• Anastasia M. Hughes,
• Sajla Singh,
• Grace-Alyssa Chua,
• Jette Ford,
• Emanuela Ferrari,
• Joyce Oommen,
• Sébastien Malinge,
• Richard B. Lock,
• Ursula R. Kees,
• Rishi S. Kotecha

Affiliations

Laurence C. Cheung

Division of Children’s Leukaemia and Cancer Research, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth;School of Pharmacy and Biomedical Sciences, Curtin University, Perth

Mark N. Cruickshank

Division of Children’s Leukaemia and Cancer Research, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth

Anastasia M. Hughes

Division of Children’s Leukaemia and Cancer Research, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth

Sajla Singh

Division of Children’s Leukaemia and Cancer Research, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth

Grace-Alyssa Chua

Division of Children’s Leukaemia and Cancer Research, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth

Jette Ford

Division of Children’s Leukaemia and Cancer Research, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth

Emanuela Ferrari

Division of Children’s Leukaemia and Cancer Research, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth

Joyce Oommen

Division of Children’s Leukaemia and Cancer Research, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth

Sébastien Malinge

Division of Children’s Leukaemia and Cancer Research, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth

Richard B. Lock

Children’s Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney

Ursula R. Kees

Division of Children’s Leukaemia and Cancer Research, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth

Rishi S. Kotecha

Division of Children’s Leukaemia and Cancer Research, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth;School of Pharmacy and Biomedical Sciences, Curtin University, Perth;Department of Haematology and Oncology, Perth Children’s Hospital, Perth;Division of Paediatrics, School of Medicine, University of Western Australia, Perth, Australia