Influence of psychopathology and metabolic parameters on quality of life in patients with first-episode psychosis before and after initial antipsychotic treatment
Anne Sofie A. Dahl,
Victor Sørensen,
Karen S. Ambrosen,
Mikkel E. Sørensen,
Grímur H. Mohr,
Mette Ø. Nielsen,
Kirsten B. Bojesen,
Birte Y. Glenthøj,
Margaret Hahn,
Julie Midtgaard,
Bjørn H. Ebdrup
Affiliations
Anne Sofie A. Dahl
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) & Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen University Hospital—Mental Health Services Copenhagen
Victor Sørensen
Centre for Applied Research in Mental Health Care (CARMEN), Copenhagen University Hospital—Mental Health Services Copenhagen
Karen S. Ambrosen
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) & Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen University Hospital—Mental Health Services Copenhagen
Mikkel E. Sørensen
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) & Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen University Hospital—Mental Health Services Copenhagen
Grímur H. Mohr
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) & Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen University Hospital—Mental Health Services Copenhagen
Mette Ø. Nielsen
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) & Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen University Hospital—Mental Health Services Copenhagen
Kirsten B. Bojesen
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) & Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen University Hospital—Mental Health Services Copenhagen
Birte Y. Glenthøj
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) & Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen University Hospital—Mental Health Services Copenhagen
Margaret Hahn
Schizophrenia Division, Centre for Addiction and Mental Health (CAMH)
Julie Midtgaard
Centre for Applied Research in Mental Health Care (CARMEN), Copenhagen University Hospital—Mental Health Services Copenhagen
Bjørn H. Ebdrup
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) & Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen University Hospital—Mental Health Services Copenhagen
Abstract The impact of psychological and physical health on quality of life (QoL) in patients with early psychosis remain relatively unexplored. We evaluated the predictive value of psychopathological and metabolic parameters on QoL in antipsychotic-naïve patients with first-episode psychosis before and after initial antipsychotic treatment. At baseline, 125 patients underwent assessments of psychopathology, prevalence of metabolic syndrome (MetS), and QoL. After 6 weeks of antipsychotic monotherapy, 89 patients were re-investigated. At baseline, the prevalence of MetS was 19.3% (n = 22). After 6 weeks, body weight (1.3 kg, p < 0.001) and body mass index (0.4 kg/m2, p < 0.001) increased, and four additional patients developed MetS. Multivariate linear regression revealed that positive and negative symptoms, and to some degree waist circumference, were predictors of QoL at both time points. Our findings suggest that in the earliest stages of antipsychotic treatment, metabolic side-effects may be less influential on QoL than psychopathological severity.
