Antioxidants
(Nov 2021)
Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study
Virgile Clergue-Duval,
Julien Azuar,
Julien Fonsart,
Clément Delage,
Dorian Rollet,
Jihed Amami,
Alexia Frapsauce,
Marie-Astrid Gautron,
Eric Hispard,
Frank Bellivier,
Vanessa Bloch,
Jean-Louis Laplanche,
Frank Questel,
Florence Vorspan
Affiliations
Virgile Clergue-Duval
APHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, France
Julien Azuar
APHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, France
Julien Fonsart
APHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Biochimie et Biologie Moléculaire, 75010 Paris, France
Clément Delage
Inserm UMRS-1144 Optimisation Thérapeutique en Neuropsychopharmacologie, Université de Paris, 75006 Paris, France
Dorian Rollet
APHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, France
Jihed Amami
APHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, France
Alexia Frapsauce
APHP GHU Nord, Site Lariboisière Fernand-Widal, Service de Pharmacie, 75010 Paris, France
Marie-Astrid Gautron
FHU Network of Research in Substance Use Disorders (NOR-SUD), 75006 Paris, France
Eric Hispard
APHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, France
Frank Bellivier
APHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, France
Vanessa Bloch
Inserm UMRS-1144 Optimisation Thérapeutique en Neuropsychopharmacologie, Université de Paris, 75006 Paris, France
Jean-Louis Laplanche
Inserm UMRS-1144 Optimisation Thérapeutique en Neuropsychopharmacologie, Université de Paris, 75006 Paris, France
Frank Questel
APHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, France
Florence Vorspan
APHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, France
DOI
https://doi.org/10.3390/antiox10121892
Journal volume & issue
Vol. 10,
no. 12
Abstract
Read online
Malnutrition has been reported in alcohol use disorder patients as having a possible influence on cognitive function. The aim of this study was to analyse the prevalence of ascorbic acid (AA) deficiency in inpatients admitted for alcohol detoxification and the associated factors, including cognitive impairment in the early period of abstinence. A retrospective chart review was conducted. The AA level was categorised into three groups: deficiency (AAD) (p = 0.037) and sedative use disorder (β = −2.77, p = 0.046) were associated with the MoCA score. AAD and AAI are frequent in inpatients admitted for alcohol detoxification. A low level of AA was associated with cognitive impairment in the early period of abstinence.
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