This study aimed to analyze the perceptions of students with disabilities regarding the barriers to inclusion in higher education institutions in northeastern Colombia. Employing a mixed-methods approach, data were collected through questionnaires and semi-structured interviews with 28 students with disabilities, focusing on socio-demographic data and their personal university experiences. The findings revealed that physical and visual impairments were the most common (34.6% each) and the primary barriers were insufficient pedagogical strategies. An association between the type of disability and perceived support was identified. In conclusion, this study enabled the development of a comprehensive model for university inclusion in the northeastern region.