Nature Communications (May 2018)

CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema

  • Gabriela D. García Nores,
  • Catherine L. Ly,
  • Daniel A. Cuzzone,
  • Raghu P. Kataru,
  • Geoffrey E. Hespe,
  • Jeremy S. Torrisi,
  • Jung Ju Huang,
  • Jason C. Gardenier,
  • Ira L. Savetsky,
  • Matthew D. Nitti,
  • Jessie Z. Yu,
  • Sonia Rehal,
  • Babak J. Mehrara

DOI
https://doi.org/10.1038/s41467-018-04418-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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CD4+ T cells are critical for the development of lymphedema. Here the authors show how these cells contribute to lymphedema and identify that the sphingosine-1-phosphate receptor modulator FTY720 can prevent lymphedema in a mouse tail injury model by blocking the release of CD4+ T cells from the lymph nodes to the skin.