Nature Communications (Jul 2022)
Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity
- James J. Gilchrist,
- Seiko Makino,
- Vivek Naranbhai,
- Piyush K. Sharma,
- Surya Koturan,
- Orion Tong,
- Chelsea A. Taylor,
- Robert A. Watson,
- Alba Verge de los Aires,
- Rosalin Cooper,
- Evelyn Lau,
- Sara Danielli,
- Dan Hameiri-Bowen,
- Wanseon Lee,
- Esther Ng,
- Justin Whalley,
- Julian C. Knight,
- Benjamin P. Fairfax
Affiliations
- James J. Gilchrist
- Department of Paediatrics, University of Oxford
- Seiko Makino
- Wellcome Centre for Human Genetics, University of Oxford
- Vivek Naranbhai
- Wellcome Centre for Human Genetics, University of Oxford
- Piyush K. Sharma
- MRC-Weatherall Institute of Molecular Medicine, University of Oxford
- Surya Koturan
- MRC-Weatherall Institute of Molecular Medicine, University of Oxford
- Orion Tong
- MRC-Weatherall Institute of Molecular Medicine, University of Oxford
- Chelsea A. Taylor
- MRC-Weatherall Institute of Molecular Medicine, University of Oxford
- Robert A. Watson
- MRC-Weatherall Institute of Molecular Medicine, University of Oxford
- Alba Verge de los Aires
- MRC-Weatherall Institute of Molecular Medicine, University of Oxford
- Rosalin Cooper
- MRC-Weatherall Institute of Molecular Medicine, University of Oxford
- Evelyn Lau
- Wellcome Centre for Human Genetics, University of Oxford
- Sara Danielli
- Wellcome Centre for Human Genetics, University of Oxford
- Dan Hameiri-Bowen
- Wellcome Centre for Human Genetics, University of Oxford
- Wanseon Lee
- Wellcome Centre for Human Genetics, University of Oxford
- Esther Ng
- Wellcome Centre for Human Genetics, University of Oxford
- Justin Whalley
- Wellcome Centre for Human Genetics, University of Oxford
- Julian C. Knight
- Wellcome Centre for Human Genetics, University of Oxford
- Benjamin P. Fairfax
- MRC-Weatherall Institute of Molecular Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-022-31626-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Natural Killer cells are key mediators of anti-tumour immunosurveillance and anti-viral immunity. Here, the authors map regulatory genetic variation in primary Natural Killer cells, providing new insights into their role in human health and disease.
