Intracellular Cholesterol Synthesis and Transport

Qingyang Shi; Jiahuan Chen; Xiaodong Zou; Xiaochun Tang; Xiaochun Tang

doi:10.3389/fcell.2022.819281

Frontiers in Cell and Developmental Biology (Mar 2022)

Intracellular Cholesterol Synthesis and Transport

Qingyang Shi,
Jiahuan Chen,
Xiaodong Zou,
Xiaochun Tang,
Xiaochun Tang

Affiliations

Qingyang Shi: Center of Reproductive Medicine and Center of Prenatal Diagnosis, The First Hospital, Jilin University, Changchun, China
Jiahuan Chen: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, Changchun, China
Xiaodong Zou: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, Changchun, China
Xiaochun Tang: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, Changchun, China
Xiaochun Tang: Chongqing Research Institute of Jilin University, Chongqing, China

DOI: https://doi.org/10.3389/fcell.2022.819281
Journal volume & issue: Vol. 10

Abstract

Read online

Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in cells are balanced dynamically by uptake, biosynthesis, transport, distribution, esterification, and export. In this review, we focus on de novo cholesterol synthesis, cholesterol synthesis regulation, and intracellular cholesterol trafficking. In addition, the progression of lipid transfer proteins (LTPs) at multiple contact sites between organelles is considered.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

About the journal

Abstract

Keywords