Host interneurons mediate plasticity reactivated by embryonic inhibitory cell transplantation in mouse visual cortex

XiaoTing Zheng; Kirstie J. Salinas; Dario X. Figueroa Velez; Taylor Nakayama; Xiaoxiao Lin; Dhruba Banerjee; Xiangmin Xu; Sunil P. Gandhi

doi:10.1038/s41467-021-21097-4

Nature Communications (Feb 2021)

Host interneurons mediate plasticity reactivated by embryonic inhibitory cell transplantation in mouse visual cortex

XiaoTing Zheng,
Kirstie J. Salinas,
Dario X. Figueroa Velez,
Taylor Nakayama,
Xiaoxiao Lin,
Dhruba Banerjee,
Xiangmin Xu,
Sunil P. Gandhi

Affiliations

XiaoTing Zheng: Department of Neurobiology and Behavior, University of California, Irvine
Kirstie J. Salinas: Department of Neurobiology and Behavior, University of California, Irvine
Dario X. Figueroa Velez: Department of Neurobiology and Behavior, University of California, Irvine
Taylor Nakayama: Department of Neurobiology and Behavior, University of California, Irvine
Xiaoxiao Lin: Department of Anatomy and Neurobiology, University of California, Irvine
Dhruba Banerjee: Department of Neurobiology and Behavior, University of California, Irvine
Xiangmin Xu: Department of Anatomy and Neurobiology, University of California, Irvine
Sunil P. Gandhi: Department of Neurobiology and Behavior, University of California, Irvine

DOI: https://doi.org/10.1038/s41467-021-21097-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Transplantation of embryonic interneurons can restore juvenile plasticity to the adult host visual cortex. Here, the authors show that transplanted embryonic interneurons reactivate cortical plasticity via Neuregulin/ErbB4 signaling in host parvalbumin interneurons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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