Nature Communications (Feb 2021)

Host interneurons mediate plasticity reactivated by embryonic inhibitory cell transplantation in mouse visual cortex

  • XiaoTing Zheng,
  • Kirstie J. Salinas,
  • Dario X. Figueroa Velez,
  • Taylor Nakayama,
  • Xiaoxiao Lin,
  • Dhruba Banerjee,
  • Xiangmin Xu,
  • Sunil P. Gandhi

DOI
https://doi.org/10.1038/s41467-021-21097-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Transplantation of embryonic interneurons can restore juvenile plasticity to the adult host visual cortex. Here, the authors show that transplanted embryonic interneurons reactivate cortical plasticity via Neuregulin/ErbB4 signaling in host parvalbumin interneurons.