Diagnostic Arthroscopy of the Minipig Stifle (Knee) for Translational Large Animal Research

Dean Wang, M.D.; Mark Cubberly, M.D.; Wendy E. Brown, Ph.D.; Heenam Kwon, Ph.D.; Jerry C. Hu, Ph.D.; Kyriacos A. Athanasiou, Ph.D.

Arthroscopy Techniques (Feb 2021)

Diagnostic Arthroscopy of the Minipig Stifle (Knee) for Translational Large Animal Research

Dean Wang, M.D.,
Mark Cubberly, M.D.,
Wendy E. Brown, Ph.D.,
Heenam Kwon, Ph.D.,
Jerry C. Hu, Ph.D.,
Kyriacos A. Athanasiou, Ph.D.

Affiliations

Dean Wang, M.D.: Department of Orthopaedic Surgery, University of California Irvine, Irvine, California, U.S.A.; Address correspondence to Dean Wang, M.D., Department of Orthopaedic Surgery, UCI Health, 101 The City Dr S, Pav III, Orange, CA 92868, U.S.A.
Mark Cubberly, M.D.: Department of Orthopaedic Surgery, University of California Irvine, Irvine, California, U.S.A.
Wendy E. Brown, Ph.D.: Department of Biomedical Engineering, University of California Irvine, Irvine, California, U.S.A.
Heenam Kwon, Ph.D.: Department of Biomedical Engineering, University of California Irvine, Irvine, California, U.S.A.
Jerry C. Hu, Ph.D.: Department of Biomedical Engineering, University of California Irvine, Irvine, California, U.S.A.
Kyriacos A. Athanasiou, Ph.D.: Department of Biomedical Engineering, University of California Irvine, Irvine, California, U.S.A.

Journal volume & issue: Vol. 10, no. 2
pp. e297 – e301

Abstract

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To gain regulatory approval for the clinical use of knee biologics and devices in humans, translational large-animal studies are typically required. Animal models that permit second-look arthroscopy are valuable because they allow for longitudinal assessment of the treated tissue without needing to sacrifice the animal. The minipig is an ideal preclinical animal model for the investigation of therapies for the knee, in part because arthroscopy can be performed in its stifle (knee) joint with the use of standard surgical equipment used in humans. The purpose of this Technical Note is to describe a reproducible technique for diagnostic arthroscopy of the minipig stifle (knee) joint.

Published in Arthroscopy Techniques

ISSN: 2212-6287 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Surgery: Orthopedic surgery
Website: https://www.journals.elsevier.com/arthroscopy-techniques

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