Nature Communications (May 2018)
Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders
- Yao Xiao,
- Can Wang,
- Jia-Yu Chen,
- Fujian Lu,
- Jue Wang,
- Ning Hou,
- Xiaomin Hu,
- Fanxin Zeng,
- Dongwei Ma,
- Xueting Sun,
- Yi Ding,
- Yan Zhang,
- Wen Zheng,
- Yuli Liu,
- Haibao Shang,
- Wenzhen Zhu,
- Chensheng Han,
- Yulin Zhang,
- Kunfu Ouyang,
- Liangyi Chen,
- Ju Chen,
- Rui-Ping Xiao,
- Chuan-Yun Li,
- Xiuqin Zhang
Affiliations
- Yao Xiao
- Institute of Molecular Medicine, Peking University
- Can Wang
- Institute of Molecular Medicine, Peking University
- Jia-Yu Chen
- Institute of Molecular Medicine, Peking University
- Fujian Lu
- Institute of Molecular Medicine, Peking University
- Jue Wang
- Institute of Molecular Medicine, Peking University
- Ning Hou
- Institute of Molecular Medicine, Peking University
- Xiaomin Hu
- Institute of Molecular Medicine, Peking University
- Fanxin Zeng
- Institute of Molecular Medicine, Peking University
- Dongwei Ma
- Institute of Molecular Medicine, Peking University
- Xueting Sun
- Institute of Molecular Medicine, Peking University
- Yi Ding
- Institute of Molecular Medicine, Peking University
- Yan Zhang
- Institute of Molecular Medicine, Peking University
- Wen Zheng
- Institute of Molecular Medicine, Peking University
- Yuli Liu
- Institute of Molecular Medicine, Peking University
- Haibao Shang
- Institute of Molecular Medicine, Peking University
- Wenzhen Zhu
- Institute of Molecular Medicine, Peking University
- Chensheng Han
- Institute of Molecular Medicine, Peking University
- Yulin Zhang
- Institute of Molecular Medicine, Peking University
- Kunfu Ouyang
- Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School
- Liangyi Chen
- Institute of Molecular Medicine, Peking University
- Ju Chen
- Department of Medicine, University of California San Diego School of Medicine
- Rui-Ping Xiao
- Institute of Molecular Medicine, Peking University
- Chuan-Yun Li
- Institute of Molecular Medicine, Peking University
- Xiuqin Zhang
- Institute of Molecular Medicine, Peking University
- DOI
- https://doi.org/10.1038/s41467-018-04352-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Hyperinsulinemia can precede the development of insulin resistance. Here the authors identify a PKD2 mutation that leads to hyperinsulinemia and insulin resistance in Rhesus monkey and show that PKD2 deficiency promotes beta cell insulin secretion by activating L-type Ca2+ channels.
