Effects and safety of continuous infusion of cisatracurium in laparoscopic abdominal surgery

Abstract

Objective To explore the effects and safety of continuous infusion of cisatracurium in laparoscopic abdominal surgery. Methods Ninety patients undergoing elective laparoscopic abdominal surgery in Gubei Branch of Ruijin Hospital from January 2019 to January 2020 were randomly divided into continuous infusion group (n=45) and intermittent infusion group (n=45). Parameters including dosage of cisatracurium, onset time, lack of muscle relaxant occurrences, extubation time, recovery index, which was stimulation with train of four(TOF) and T1 recovery from 25% to 75%, TOF 70% (recovery time for 70% from drug withdrawal to TOF), TOF 90%(recovery time for 90% from drug withdrawal to TOF), both mean arterial pressure and heart rate during anesthesia and during induction, and adverse reactions were compared between two groups. Results There was no significant difference in onset time of cisatracurium between two groups(P=0.102). Lack of muscle relaxant occurrences(P=0.003) and dosage of cisatracurium (P<0.001) in continuous infusion group was significantly lower than those in intermittent infusion group. There was no significant difference in extubation time between two groups (P=0.095). Recovery index, TOF 70% and TOF 90% in continuous infusion group were significantly lower than those in intermittent infusion group (P<0.001). There was no significant difference in both mean arterial pressure and heart rate during anesthesia and during induction(P>0.05) and in the incidence of adverse reactions(P>0.05) between two groups. Conclusions Compared with intermittent infusion, continuous infusion of cisatracurium in laparoscopic abdominal surgery could have more effect of muscle relaxation, reduce the dosage of cisatracurium, shorten recovery index and reduce adverse reactions.

Keywords

• |cisatracurium|continuous infusion|laparoscopic abdominal surgery