A Study of Anomaly Producing Effects of Disodium Hemiphtalate Glycyrrhetinic Acid on Skleton of Mice Embryo

Abstract

Disodium hemiphthalate Glycyrrhetinic acid (DHGA) possesses anti-inflammatory and analgestic activities. In our research, this agent was injected intraperitoneally to mice, according to the following schedule."n1) 25 mg/kg, 50mg/kg & 75mg/kg at 7th day of pregnancy."n2) 50 mg/kg & 75mg/kg at 8th day of pregnancy."n3) 50mg/kg & 75mg/kg at 9th day of pregnancy."nDHGA with doses of 50mg/kg and 75mg/kg at 7th, 8th and 9th day, delays the growth, decreases developing of ossification centers (specially in hand and foot middle phalanxes), decreases the number of caudal vertebrae of sacro-illiac joint and results in slight but important increases in fetus mortality."nAbbreviations"nH & E=Haematoxylin & Eosin"nCRL=Crown-Rump Length"nBPD=Biparietal Diameter"nW=Weight"nETS=Embryo Toxicity Score