Nature Communications (Jan 2019)
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response
- Yael Haberman,
- Rebekah Karns,
- Phillip J. Dexheimer,
- Melanie Schirmer,
- Judith Somekh,
- Ingrid Jurickova,
- Tzipi Braun,
- Elizabeth Novak,
- Laura Bauman,
- Margaret H. Collins,
- Angela Mo,
- Michael J. Rosen,
- Erin Bonkowski,
- Nathan Gotman,
- Alison Marquis,
- Mason Nistel,
- Paul A. Rufo,
- Susan S. Baker,
- Cary G. Sauer,
- James Markowitz,
- Marian D. Pfefferkorn,
- Joel R. Rosh,
- Brendan M. Boyle,
- David R. Mack,
- Robert N. Baldassano,
- Sapana Shah,
- Neal S. Leleiko,
- Melvin B. Heyman,
- Anne M. Grifiths,
- Ashish S. Patel,
- Joshua D. Noe,
- Bruce J. Aronow,
- Subra Kugathasan,
- Thomas D. Walters,
- Greg Gibson,
- Sonia Davis Thomas,
- Kevin Mollen,
- Shai Shen-Orr,
- Curtis Huttenhower,
- Ramnik J. Xavier,
- Jeffrey S. Hyams,
- Lee A. Denson
Affiliations
- Yael Haberman
- Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine
- Rebekah Karns
- Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine
- Phillip J. Dexheimer
- Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine
- Melanie Schirmer
- Broad Institute of MIT and Harvard University
- Judith Somekh
- Faculty of Medicine, Technion
- Ingrid Jurickova
- Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine
- Tzipi Braun
- Sheba Medical Center, Tel Hashomer, affiliated with the Tel Aviv University
- Elizabeth Novak
- Children’s Hospital of Pittsburgh
- Laura Bauman
- Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine
- Margaret H. Collins
- Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine
- Angela Mo
- Georgia Institute of Technology
- Michael J. Rosen
- Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine
- Erin Bonkowski
- Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine
- Nathan Gotman
- Collaborative Studies Coordinating Center, University of North Carolina
- Alison Marquis
- Collaborative Studies Coordinating Center, University of North Carolina
- Mason Nistel
- Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine
- Paul A. Rufo
- Harvard—Children’s Hospital Boston
- Susan S. Baker
- Women & Children’s Hospital of Buffalo WCHOB
- Cary G. Sauer
- Emory University
- James Markowitz
- Cohen Children’s Medical Center of New York
- Marian D. Pfefferkorn
- Riley Hospital for Children
- Joel R. Rosh
- Goryeb Children’s Hospital—Atlantic Health
- Brendan M. Boyle
- Nationwide Children’s Hospital
- David R. Mack
- Children’s Hospital of East Ontario, Ottawa
- Robert N. Baldassano
- The Children’s Hospital of Philadelphia
- Sapana Shah
- Children’s Hospital of Pittsburgh of UPMC
- Neal S. Leleiko
- Hasbro Children’s Hospital
- Melvin B. Heyman
- University of California at San Francisco
- Anne M. Grifiths
- Hospital for Sick Children
- Ashish S. Patel
- UT Southwestern
- Joshua D. Noe
- Medical College of Wisconsin
- Bruce J. Aronow
- Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine
- Subra Kugathasan
- Emory University
- Thomas D. Walters
- Hospital for Sick Children
- Greg Gibson
- Georgia Institute of Technology
- Sonia Davis Thomas
- Collaborative Studies Coordinating Center, University of North Carolina
- Kevin Mollen
- Children’s Hospital of Pittsburgh
- Shai Shen-Orr
- Faculty of Medicine, Technion
- Curtis Huttenhower
- Broad Institute of MIT and Harvard University
- Ramnik J. Xavier
- Broad Institute of MIT and Harvard University
- Jeffrey S. Hyams
- Connecticut Children’s Medical Center
- Lee A. Denson
- Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-07841-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The severity of ulcerative colitis, and response to treatment, is highly variable. Here, the authors examine rectal gene expression signatures and faecal microbiomes of children and adults with the disease and provide new insights in to pathogenesis.
