Nucleocapsid Protein as Early Diagnostic Marker for SARS

Abstract

Serum samples from 317 patients with patients with severe acute respiratory syndrome (SARS) were tested for the nucleocapsid (N) protein of SARS-associated coronavirus, with sensitivities of 94% and 78% for the first 5 days and 6–10 days after onset, respectively. The specificity was 99.9%. N protein can be used as an early diagnostic maker for SARS.

Keywords

• SARS-CoV
• nucleocapsid protein, monoclonal antibody, enzyme-linked immunosorbent assay, early diagnosis, severe acute respiratory syndrome, dispatch
• China