Nature Communications (Jul 2022)
Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children
- Jo-Anne Chan,
- Jessica R. Loughland,
- Lauren de la Parte,
- Satomi Okano,
- Isaac Ssewanyana,
- Mayimuna Nalubega,
- Felistas Nankya,
- Kenneth Musinguzi,
- John Rek,
- Emmanuel Arinaitwe,
- Peta Tipping,
- Peter Bourke,
- Dean Andrew,
- Nicholas Dooley,
- Arya SheelaNair,
- Bruce D. Wines,
- P. Mark Hogarth,
- James G. Beeson,
- Bryan Greenhouse,
- Grant Dorsey,
- Moses Kamya,
- Gunter Hartel,
- Gabriela Minigo,
- Margaret Feeney,
- Prasanna Jagannathan,
- Michelle J. Boyle
Affiliations
- Jo-Anne Chan
- Burnet Institute
- Jessica R. Loughland
- QIMR-Berghofer Medical Research Institute
- Lauren de la Parte
- Department of Medicine, Stanford University
- Satomi Okano
- QIMR-Berghofer Medical Research Institute
- Isaac Ssewanyana
- Infectious Diseases Research Collaboration
- Mayimuna Nalubega
- QIMR-Berghofer Medical Research Institute
- Felistas Nankya
- Infectious Diseases Research Collaboration
- Kenneth Musinguzi
- Infectious Diseases Research Collaboration
- John Rek
- Infectious Diseases Research Collaboration
- Emmanuel Arinaitwe
- Infectious Diseases Research Collaboration
- Peta Tipping
- Global and Tropical Health Division, Menzies School of Health Research
- Peter Bourke
- Division of Medicine, Cairns Hospital
- Dean Andrew
- QIMR-Berghofer Medical Research Institute
- Nicholas Dooley
- QIMR-Berghofer Medical Research Institute
- Arya SheelaNair
- QIMR-Berghofer Medical Research Institute
- Bruce D. Wines
- Burnet Institute
- P. Mark Hogarth
- Burnet Institute
- James G. Beeson
- Burnet Institute
- Bryan Greenhouse
- University of California San Francisco
- Grant Dorsey
- University of California San Francisco
- Moses Kamya
- Infectious Diseases Research Collaboration
- Gunter Hartel
- QIMR-Berghofer Medical Research Institute
- Gabriela Minigo
- Global and Tropical Health Division, Menzies School of Health Research
- Margaret Feeney
- University of California San Francisco
- Prasanna Jagannathan
- Department of Medicine, Stanford University
- Michelle J. Boyle
- Burnet Institute
- DOI
- https://doi.org/10.1038/s41467-022-31880-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Despite being key drivers of protective antibodies against malaria, little is known regarding the host and parasite factors that influence CD4 T-follicular helper cell and antibody development. Authors utilise samples from a study of children living in an area of high malaria transmission in Uganda, to characterize Tfh cells and functional antibodies to multiple parasites stages.
