Diabetes, Metabolic Syndrome and Obesity (Apr 2024)

Metabolic Syndrome and Tendon Disease: A Comprehensive Review

  • Lai C,
  • Li R,
  • Tang W,
  • Liu J,
  • Duan XD,
  • Bao D,
  • Liu H,
  • Fu S

Journal volume & issue
Vol. Volume 17
pp. 1597 – 1609

Abstract

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Canhao Lai,1,* Ruichen Li,1,* Weili Tang,1 Jinyu Liu,1 Xinfang DXF Duan,1 Dingsu Bao,1,2 Huan Liu,1 Shijie Fu1 1Department of Bone and Joint, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, People’s Republic of China; 2Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shijie Fu; Huan Liu, Department of Bone and Joint, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, No. 182, Chunhui Road, Longmatan District, Luzhou, Sichuan, 646000, People’s Republic of China, Tel +86 13882759783, Email [email protected]; [email protected]: Metabolic syndrome (MS) is a multifaceted pathological condition characterized by the atypical accumulation of various metabolic components such as central obesity or excess weight, hyperlipidemia, low-density lipoprotein (LDL), hypertension, and insulin resistance. Recently, MS has been recognized as a notable contributor to heart and circulatory diseases. In addition, with increasing research, the impact of MS on tendon repair and disease has gradually emerged. Recent studies have investigated the relationship between tendon healing and diseases such as diabetes, dyslipidemia, obesity, and other metabolic disorders. However, diabetes mellitus (DM), hypercholesterolemia, obesity, and various metabolic disorders often coexist and together constitute MS. At present, insulin resistance is considered the major pathological mechanism underlying MS, central obesity is regarded as the predominant factor responsible for it, and dyslipidemia and other metabolic diseases are known as secondary contributors to MS. This review aims to evaluate the current literature regarding the impact of various pathological conditions in MS on tendon recovery and illness, and to present a comprehensive overview of the effects of MS on tendon recovery and diseases, along with the accompanying molecular mechanisms.Keywords: metabolic syndrome, tendon, diabetes mellitus, hyperlipidemia, obesity, hypertension

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