PLoS ONE (Jan 2013)

Diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies.

  • Xin Xu,
  • Jian Wu,
  • Yeqing Mao,
  • Yi Zhu,
  • Zhenghui Hu,
  • Xianglai Xu,
  • Yiwei Lin,
  • Hong Chen,
  • Xiangyi Zheng,
  • Jie Qin,
  • Liping Xie

DOI
https://doi.org/10.1371/journal.pone.0058079
Journal volume & issue
Vol. 8, no. 3
p. e58079

Abstract

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ObjectiveDiabetes is associated with increased risk of cancer at several sites, but its association with risk of bladder cancer is still controversial. We examined this association by conducting a systematic review and meta-analysis of cohort studies.MethodsStudies were identified by searching PubMed, EMBASE, Scopus, Web of Science, Cochrane register, and Chinese National Knowledge Infrastructure (CNKI) databases through April 29, 2012. Summary relative risks (SRRs) with their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model.ResultsA total of fifteen cohort studies were included in this meta-analysis. Analysis of all studies showed that diabetes was associated with a borderline statistically significant increased risk of bladder cancer (RR 1.11, 95% CI 1.00-1.23; pConclusionsOur findings support that diabetes was associated with an increased risk of bladder cancer. More future studies are warranted to get a better understanding of the association and to provide convincing evidence for clinical practice in bladder cancer prevention.