Bladder cancer-associated microbiota: Recent advances and future perspectives
Wentao Zhang,
Fuhan Yang,
Shiyu Mao,
Ruiliang Wang,
Haotian Chen,
Yuefei Ran,
Shenghua Liu,
Pengfei Wu,
Yang Yan,
Wei Li,
Junfeng Zhang,
Xudong Yao
Affiliations
Wentao Zhang
Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Fuhan Yang
Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Shiyu Mao
Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Ruiliang Wang
Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Haotian Chen
Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Yuefei Ran
Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China; Shanghai Clinical College, Anhui Medical University, Hefei, China
Shenghua Liu
Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Pengfei Wu
Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Yang Yan
Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Wei Li
Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China; Corresponding author.Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China.
Junfeng Zhang
Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China; Corresponding author.Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China.
Xudong Yao
Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China; Corresponding author.Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China.
Recent evidence suggests that the human genitourinary microbiome plays a significant role in mediating the development and progression of urological tumors, including bladder cancer (BC). Clinicians widely recognize the role of Bacille Calmette Guérin (BCG), an attenuated Mycobacterium tuberculosis vaccine, in the management of intermediate- and high-risk NMIBC. However, compared to the large body of evidence on the gut microbiota and gastrointestinal tumors, limited information is available about the interaction between BC and the genitourinary microbiome. This is an expanding field that merits further investigation. Urologists will need to consider the potential impact of the microbiome in BC diagnosis, prevention of recurrence and progression, and treatment prospects in the future. This review highlights the approaches adopted for microbiome research and the findings and inadequacies of current research on BC.
