An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

Song Zhu; Ji-Zhong Wang; De Chen; Yu-Tian He; Nan Meng; Min Chen; Rui-Xun Lu; Xin-Hui Chen; Xiao-Lan Zhang; Guang-Rong Yan

doi:10.1038/s41467-020-15403-9

Nature Communications (Apr 2020)

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

Song Zhu,
Ji-Zhong Wang,
De Chen,
Yu-Tian He,
Nan Meng,
Min Chen,
Rui-Xun Lu,
Xin-Hui Chen,
Xiao-Lan Zhang,
Guang-Rong Yan

Affiliations

Song Zhu: Biomedicine Research Center, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University
Ji-Zhong Wang: Biomedicine Research Center, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University
De Chen: Biomedicine Research Center, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University
Yu-Tian He: Biomedicine Research Center, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University
Nan Meng: Biomedicine Research Center, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University
Min Chen: Biomedicine Research Center, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University
Rui-Xun Lu: Biomedicine Research Center, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University
Xin-Hui Chen: Biomedicine Research Center, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University
Xiao-Lan Zhang: Biomedicine Research Center, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University
Guang-Rong Yan: Biomedicine Research Center, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University

DOI: https://doi.org/10.1038/s41467-020-15403-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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The involvement of long non-coding RNA (lncRNA) in the regulation of N6-methyladenosine (m6A) modification of RNA is unclear. Here, the authors show that LINC00266-1 encodes a peptide that binds to m6A reader, IGF2BP1 to enhance the recognition of m6A modified RNA transcripts and increase their stability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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