Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats

Sung-Ho Lee; Tatiana A. Shnitko; Li-Ming Hsu; Margaret A. Broadwater; Mabelle Sardinas; Tzu-Wen Winnie Wang; Donita L. Robinson; Ryan P. Vetreno; Fulton T. Crews; Yen-Yu Ian Shih

Addiction Neuroscience (Sep 2023)

Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats

Sung-Ho Lee,
Tatiana A. Shnitko,
Li-Ming Hsu,
Margaret A. Broadwater,
Mabelle Sardinas,
Tzu-Wen Winnie Wang,
Donita L. Robinson,
Ryan P. Vetreno,
Fulton T. Crews,
Yen-Yu Ian Shih

Affiliations

Sung-Ho Lee: Center for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA; Bowles Center for Alcohol Studies University of North Carolina, Chapel Hill, NC, USA
Tatiana A. Shnitko: Center for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA
Li-Ming Hsu: Center for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA
Margaret A. Broadwater: Center for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA; Bowles Center for Alcohol Studies University of North Carolina, Chapel Hill, NC, USA
Mabelle Sardinas: Center for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA
Tzu-Wen Winnie Wang: Center for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA
Donita L. Robinson: Bowles Center for Alcohol Studies University of North Carolina, Chapel Hill, NC, USA; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
Ryan P. Vetreno: Bowles Center for Alcohol Studies University of North Carolina, Chapel Hill, NC, USA; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
Fulton T. Crews: Bowles Center for Alcohol Studies University of North Carolina, Chapel Hill, NC, USA; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA
Yen-Yu Ian Shih: Center for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA; Bowles Center for Alcohol Studies University of North Carolina, Chapel Hill, NC, USA; Corresponding author at: Center for Animal MRI, University of North Carolina, 125 Mason Farm Road, CB# 7513, Chapel Hill, NC 27599, USA

Journal volume & issue: Vol. 7
p. 100105

Abstract

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Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While evidence suggests that adolescent alcohol use affects frontal brain regions that are important for cognitive control over behavior, little is known about how acute alcohol exposure alters large-scale brain networks and how sex and age may moderate such effects. Here, we employ a recently developed functional magnetic resonance imaging (fMRI) protocol to acquire rat brain functional connectivity data and use an established analytical pipeline to examine the effect of sex, age, and alcohol dose on connectivity within and between three major rodent brain networks: default mode, salience, and lateral cortical network. We identify the intra- and inter-network connectivity differences and establish moderation models to reveal significant influences of age on acute alcohol-induced lateral cortical network connectivity. Through this work, we make brain-wide isotropic fMRI data with acute alcohol challenge publicly available, with the hope to facilitate future discovery of brain regions/circuits that are causally relevant to the impact of acute alcohol use.

Published in Addiction Neuroscience

ISSN: 2772-3925 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/addiction-neuroscience

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