Journal of Integrative Neuroscience (2020-12-01)

Danggui Sini decoction protects against oxaliplatin-induced peripheral neuropathy in rats

  • Rong Ding,
  • Yue Wang,
  • Ji-Ping Zhu,
  • Wu-Guang Lu,
  • Guo-Li Wei,
  • Zhan-Cheng Gu,
  • Zhen-Tao An,
  • Jie-Ge Huo

DOI
https://doi.org/10.31083/j.jin.2020.04.1154
Journal volume & issue
Vol. 19, no. 4
pp. 663 – 671

Abstract

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The effects of Danggui Sini decoction on peripheral neuropathy in oxaliplatin-induced peripheral is established. The results indicated that Danggui Sini decoction treatment significantly reduced the current amplitude of dorsal root ganglia cells undergoing agonists stimuli compared to the model-dorsal root ganglia group (P Danggui Sini decoction treatment significantly inhibited the inflammatory response of dorsal root ganglia cells compared to the model-dorsal root ganglia group (P Danggui Sini decoction treatment significantly enhanced the amounts of Nissl bodies in dorsal root ganglia cells compared to the Model-dorsal root ganglia group (P Danggui Sini decoction treatment improved ultra-microstructures of dorsal root ganglia cells. In conclusion, Danggui Sini decoction protected against neurotoxicity of oxaliplatin-induced peripheral neuropathy in rats by suppressing inflammatory lesions, improving ultra-microstructures, and enhancing amounts of Nissl bodies.

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