Dose-response meta-analysis of arsenic exposure in drinking water and hypertension
Afsaneh Amiri,
Yaser Mokhayeri,
Rasool Mohammadi,
Mohammad Amin Karami,
Mansour Ghaderpoori,
Bahram Kamarehie,
Ali Jafari
Affiliations
Afsaneh Amiri
Department of Environmental Health Engineering, Environmental Health Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran
Yaser Mokhayeri
Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran
Rasool Mohammadi
Assistant Professor of Epidemiology, Department of Biostatistics and Epidemiology, School of Public Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran; Nutritional Health Research Center, Health and Nutritional Department, Lorestan University of Medical Sciences, Khorramabad, Iran
Mohammad Amin Karami
Department of Environmental Health Engineering, Environmental Health Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran
Mansour Ghaderpoori
Department of Environmental Health Engineering, Environmental Health Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran
Bahram Kamarehie
Department of Environmental Health Engineering, Environmental Health Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran; Corresponding author.
Ali Jafari
Department of Environmental Health Engineering, Environmental Health Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran; Corresponding author.
Background: Based on the cross-sectional and cohort studies, exposure to As via drinking water can cause hypertension. Methods: We searched PubMed, ISI WOS, and Scopus for relevant studies up to 1 January 2018 using related keywords. The meta-analysis was done on 10 studies (n = 28255) that report Odds Ratio for hypertension. The extracted ORs between As concentration and hypertension were pooled using random effect models. Study heterogeneity was analyzed using I2. Results: The estimated adjusted OR for association between As and hypertension was 1.44 (95% CI: 1.12, 1.84) with I2 = 71%. Dose-Response analysis showed a linear relationship between As and hypertension (OR = 1.0008 95% CI: 1.0003, 1.001). In general, by increase of each unit in arsenic concentration, odds of the hypertension would increase as 0.08%. Conclusion: There was a significant relationship between As exposure and hypertension.
