Nature Communications (Jan 2023)
Discovery and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors
Abstract
Treatment of hypertension entails use of angiotensin-converting enzyme inhibitors. Here, the authors show a series of karnamicins with significant inhibitory activity and identify two unusual flavoprotein hydroxylases involved in the assembly of the fully-substituted hydroxypyridine core of karnamicins.