Light field cameras are unsuitable for further acquisition of high-quality images due to their small depth of field, insufficient spatial resolution, and poor imaging quality. To address these issues, we proposed a novel four-focal-square microlens and light field system. A square aspheric microlens array with four orthogonal focal lengths was designed, in which the aperture of a single lens was 100 μm. The square arrangement improves pixel utilization, the four focal lengths increase the depth of field, and the aspheric improves image quality. The simulations demonstrate pixel utilization rates exceeding 90%, depth-of-field ranges 6.57 times that of a single focal length, and image quality is significantly improved. We have provided a potential solution for improving the depth of field and image quality of the light field imaging system.