Nature Communications (Dec 2018)

BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment

  • Giuseppina D’Alessandro,
  • Donna Rose Whelan,
  • Sean Michael Howard,
  • Valerio Vitelli,
  • Xavier Renaudin,
  • Marek Adamowicz,
  • Fabio Iannelli,
  • Corey Winston Jones-Weinert,
  • MiYoung Lee,
  • Valentina Matti,
  • Wei Ting C. Lee,
  • Michael John Morten,
  • Ashok Raraakrishnan Venkitaraman,
  • Petr Cejka,
  • Eli Rothenberg,
  • Fabrizio d’Adda di Fagagna

DOI
https://doi.org/10.1038/s41467-018-07799-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

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Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level at DSBs.