Comprehensive proteomic profiling of serum extracellular vesicles in patients with colorectal liver metastases identifies a signature for non-invasive risk stratification and early-response evaluation

• Kuailu Lin,
• Franziska Baenke,
• Xixi Lai,
• Martin Schneider,
• Dominic Helm,
• Heike Polster,
• Venkatesh S. Rao,
• Nicole Ganig,
• Fang Cheng Wong,
• Lena Seifert,
• Adrian M. Seifert,
• Beatrix Jahnke,
• Nicole Kretschmann,
• Tjalf Ziemssen,
• Fee Klupp,
• Thomas Schmidt,
• Martin Schneider,
• Yi Han,
• Tim F. Weber,
• Verena Plodeck,
• Heiner Nebelung,
• Nathalie Schmitt,
• Felix Korell,
• Bruno C. Köhler,
• Carina Riediger,
• Jürgen Weitz,
• Nuh N. Rahbari,
• Christoph Kahlert

Affiliations

Kuailu Lin

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Franziska Baenke

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Xixi Lai

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Martin Schneider

MS-Based Protein Analysis Unit, German Cancer Research Centre (DKFZ)

Dominic Helm

MS-Based Protein Analysis Unit, German Cancer Research Centre (DKFZ)

Heike Polster

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Venkatesh S. Rao

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Nicole Ganig

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Fang Cheng Wong

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Lena Seifert

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Adrian M. Seifert

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Beatrix Jahnke

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Nicole Kretschmann

MS Center, Centre of Clinical Neuroscience, Department of Neurology, Carl Gustav Carus University Hospital Dresden

Tjalf Ziemssen

MS Center, Centre of Clinical Neuroscience, Department of Neurology, Carl Gustav Carus University Hospital Dresden

Fee Klupp

Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg

Thomas Schmidt

Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg

Martin Schneider

Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg

Yi Han

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Tim F. Weber

Diagnostic and Interventional Radiology (DiR), Heidelberg University Hospital

Verena Plodeck

Department of Diagnostic and Interventional Radiology, Carl Gustav Carus University Hospital Dresden

Heiner Nebelung

Department of Diagnostic and Interventional Radiology, Carl Gustav Carus University Hospital Dresden

Nathalie Schmitt

Department of Medical Oncology, National Center for Tumour Diseases, Liver Cancer Centre Heidelberg, University Hospital Heidelberg, University Hospital Heidelberg

Felix Korell

Department of Medical Oncology, National Center for Tumour Diseases, Liver Cancer Centre Heidelberg, University Hospital Heidelberg, University Hospital Heidelberg

Bruno C. Köhler

Department of Medical Oncology, National Center for Tumour Diseases, Liver Cancer Centre Heidelberg, University Hospital Heidelberg, University Hospital Heidelberg

Carina Riediger

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Jürgen Weitz

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden

Nuh N. Rahbari

Department of Surgery, Medical Faculty Mannheim, University Medicine Mannheim, University of Heidelberg

Christoph Kahlert

Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden