Nature Communications (Jul 2022)
A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions
- Yang Liu,
- Xianwen Zhang,
- Jianying Liu,
- Hongjie Xia,
- Jing Zou,
- Antonio E. Muruato,
- Sivakumar Periasamy,
- Chaitanya Kurhade,
- Jessica A. Plante,
- Nathen E. Bopp,
- Birte Kalveram,
- Alexander Bukreyev,
- Ping Ren,
- Tian Wang,
- Vineet D. Menachery,
- Kenneth S. Plante,
- Xuping Xie,
- Scott C. Weaver,
- Pei-Yong Shi
Affiliations
- Yang Liu
- Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
- Xianwen Zhang
- Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
- Jianying Liu
- Department of Microbiology and Immunology, University of Texas Medical Branch
- Hongjie Xia
- Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
- Jing Zou
- Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
- Antonio E. Muruato
- Department of Microbiology and Immunology, University of Texas Medical Branch
- Sivakumar Periasamy
- Department of Pathology, University of Texas Medical Branch
- Chaitanya Kurhade
- Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
- Jessica A. Plante
- Department of Microbiology and Immunology, University of Texas Medical Branch
- Nathen E. Bopp
- Department of Pathology, University of Texas Medical Branch
- Birte Kalveram
- Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
- Alexander Bukreyev
- Department of Microbiology and Immunology, University of Texas Medical Branch
- Ping Ren
- Institute for Human Infections and Immunity, University of Texas Medical Branch
- Tian Wang
- Department of Microbiology and Immunology, University of Texas Medical Branch
- Vineet D. Menachery
- Department of Microbiology and Immunology, University of Texas Medical Branch
- Kenneth S. Plante
- Department of Microbiology and Immunology, University of Texas Medical Branch
- Xuping Xie
- Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
- Scott C. Weaver
- Department of Microbiology and Immunology, University of Texas Medical Branch
- Pei-Yong Shi
- Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
- DOI
- https://doi.org/10.1038/s41467-022-31930-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
A live-attenuated COVID vaccine could enrich the current vaccine portfolio. Here, Liu et al. engineer a live-attenuated SARS-CoV-2 vaccine candidate by deleting four viral accessory genes and show immunogenicity and protection in mice and hamsters.
