Low complexity RGG-motif sequence is required for Processing body (P-body) disassembly

Raju Roy; Gitartha Das; Ishwarya Achappa Kuttanda; Nupur Bhatter; Purusharth I. Rajyaguru

doi:10.1038/s41467-022-29715-5

Nature Communications (Apr 2022)

Low complexity RGG-motif sequence is required for Processing body (P-body) disassembly

Raju Roy,
Gitartha Das,
Ishwarya Achappa Kuttanda,
Nupur Bhatter,
Purusharth I. Rajyaguru

Affiliations

Raju Roy: Department of Biochemistry, Indian Institute of Science
Gitartha Das: Department of Biochemistry, Indian Institute of Science
Ishwarya Achappa Kuttanda: Department of Biochemistry, Indian Institute of Science
Nupur Bhatter: Department of Biochemistry, Indian Institute of Science
Purusharth I. Rajyaguru: Department of Biochemistry, Indian Institute of Science

DOI: https://doi.org/10.1038/s41467-022-29715-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Processing bodies (PBs) are higher order RNA-protein complexes that determine mRNA fate. Here, the authors show Sbp1 is responsible for PB disassembly and pinpoint a repeats of arginine and glycine (RGG) motif in Sbp1 that play a key role.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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