Management and Anticoagulation Treatment of Non-Valvular Atrial Fibrillation in Elderly Patients: The Dali Study

Abstract

Hong Huang, Nai-Qing Hu, Jun-Yun Yang, Yu-Luan Xiang, Yuan-Zhao Zhu, Qian-Ru Du, Xue-Yan Yin, Jin-lin Lv, Li-Hua Li Department of Gerontology, The First Affiliated Hospital of Dali University, Dali, Yunnan Province, 671000, People’s Republic of ChinaCorrespondence: Li-Hua Li, Department of Gerontology, The First Affiliated Hospital of Dali University, Jiashibo Road 32, Dali, 671000, People’s Republic of China, Tel [phone], Fax [phone], Email [email protected]: Non-valvular atrial fibrillation (NVAF) is associated with increased stroke in elderly populations, yet anticoagulant therapy is underutilized. We analyzed clinical characteristics and anticoagulation treatment rates of elderly NVAF patients hospitalized in Dali, China, to identify potential contributing factors.Methods: We collected data for 155 elderly patients with NVAF aged ≥ 60 years, from July 01, 2020, to December 31, 2021. We analyzed the awareness rate, clinical characteristics, and anticoagulant treatment rate of atrial fibrillation (AF), and identified factors influencing treatment. Patients were followed up one year after discharge to assess vital status, cardiovascular events, and anticoagulation therapy status.Results: Among 155 patients, 52.26% were female, and the average age was 75.77 years. The awareness rate of AF was 47.74% at admission, and only 21.94% received anticoagulant therapy. After discharge, the rate of anticoagulant therapy significantly increased to 70.97%, and 89.09% used new oral anticoagulants. Thromboembolic history and persistent AF predicted anticoagulant therapy at discharge, while male gender, previous bleeding history, and antiplatelet therapy predicted non-anticoagulant therapy. Out of 133 patients who completed a one-year follow-up, 23.31% died, 3.01% had strokes, and 3.01% experienced bleeding. Anticoagulant therapy decreased to 51.96% during the follow-up year.Conclusion: Our findings highlight the low awareness rate and anticoagulant treatment rate, and high mortality among elderly NVAF patients in Dali. The development of comprehensive intervention strategies is critical to standardize AF management and improve prognosis.Keywords: non-valvular atrial fibrillation, awareness rate of atrial fibrillation, anticoagulant therapy, stroke, all-cause death

Keywords

• non-valvular atrial fibrillation
• awareness rate of atrial fibrillation
• anticoagulant therapy
• stroke
• all-cause death