Nature Communications (Dec 2017)
Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice
- Francesco De Logu,
- Romina Nassini,
- Serena Materazzi,
- Muryel Carvalho Gonçalves,
- Daniele Nosi,
- Duccio Rossi Degl’Innocenti,
- Ilaria M. Marone,
- Juliano Ferreira,
- Simone Li Puma,
- Silvia Benemei,
- Gabriela Trevisan,
- Daniel Souza Monteiro de Araújo,
- Riccardo Patacchini,
- Nigel W. Bunnett,
- Pierangelo Geppetti
Affiliations
- Francesco De Logu
- Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence
- Romina Nassini
- Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence
- Serena Materazzi
- Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence
- Muryel Carvalho Gonçalves
- Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence
- Daniele Nosi
- Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence
- Duccio Rossi Degl’Innocenti
- Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence
- Ilaria M. Marone
- Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence
- Juliano Ferreira
- Department of Pharmacology, Federal University of Santa Catarina
- Simone Li Puma
- Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence
- Silvia Benemei
- Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence
- Gabriela Trevisan
- Laboratory of Neuropsychopharmacology and Neurotoxicity, Graduate Program in Pharmacology, Federal University of Santa Maria (UFSM)
- Daniel Souza Monteiro de Araújo
- Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence
- Riccardo Patacchini
- Department of Pharmacology, Chiesi Farmaceutici SpA
- Nigel W. Bunnett
- Departments of Surgery and Pharmacology, Columbia University
- Pierangelo Geppetti
- Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence
- DOI
- https://doi.org/10.1038/s41467-017-01739-2
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Following peripheral nerve injury, influx of immune cells to the site may contribute to the development of chronic pain. Here the authors show that TRPA1 is expressed on Schwann cells and contributes to immune cell influx in a mouse model of neuropathic pain.
