H3K27ac nucleosomes facilitate HMGN localization at regulatory sites to modulate chromatin binding of transcription factors

Shaofei Zhang; Yuri Postnikov; Alexei Lobanov; Takashi Furusawa; Tao Deng; Michael Bustin

doi:10.1038/s42003-022-03099-0

Communications Biology (Feb 2022)

H3K27ac nucleosomes facilitate HMGN localization at regulatory sites to modulate chromatin binding of transcription factors

Shaofei Zhang,
Yuri Postnikov,
Alexei Lobanov,
Takashi Furusawa,
Tao Deng,
Michael Bustin

Affiliations

Shaofei Zhang: Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute
Yuri Postnikov: Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute
Alexei Lobanov: CCR Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Takashi Furusawa: Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute
Tao Deng: Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute
Michael Bustin: Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute

DOI: https://doi.org/10.1038/s42003-022-03099-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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The nucleosome-binding proteins HMGN1 and HMGN2 prefer acetylated nucleosomes at H3K27ac and the loss of this interaction alters binding of transcription factors to chromatin.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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