Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes

Paul M. H. Tran; Fran Dong; Eileen Kim; Katherine P. Richardson; Lynn K. H. Tran; Kathleen Waugh; Diane Hopkins; Richard D. Cummings; Peng George Wang; Marian J. Rewers; Jin-Xiong She; Sharad Purohit

doi:10.1038/s41467-022-34341-2

Nature Communications (Nov 2022)

Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes

Paul M. H. Tran,
Fran Dong,
Eileen Kim,
Katherine P. Richardson,
Lynn K. H. Tran,
Kathleen Waugh,
Diane Hopkins,
Richard D. Cummings,
Peng George Wang,
Marian J. Rewers,
Jin-Xiong She,
Sharad Purohit

Affiliations

Paul M. H. Tran: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University
Fran Dong: Barbara Davis Center for Diabetes, University of Colorado Denver, Mail Stop A-140
Eileen Kim: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University
Katherine P. Richardson: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University
Lynn K. H. Tran: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University
Kathleen Waugh: Barbara Davis Center for Diabetes, University of Colorado Denver, Mail Stop A-140
Diane Hopkins: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University
Richard D. Cummings: Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School
Peng George Wang: School of Medicine, Southern University of Science and Technology
Marian J. Rewers: Barbara Davis Center for Diabetes, University of Colorado Denver, Mail Stop A-140
Jin-Xiong She: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University
Sharad Purohit: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University

DOI: https://doi.org/10.1038/s41467-022-34341-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Type I diabetes is characterized by autoantibodies directed against protein or non-protein self-antigens. Here the authors profile glycan reactive anti-carbohydrate antibodies (ACA) in a longitudinal and cross-sectional childhood diabetes cohort and associate clusters of ACA with disease progression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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