This review aims to provide a detailed overview of the botanical, phytochemical, and dermatological properties of Juglans regia (J. regia). The entire tree contains a wealth of chemical compounds, including phenols, tannins, alkaloids, saponins, reducing sugars, and amino acids, which contribute to its significant nutritional and pharmacological value. Extracts and oils from all parts of J. regia have been studied for their effects on various skin conditions, demonstrating antioxidant, antimicrobial, anti-inflammatory, UV-protective, and chemoprotective properties. Additionally, these substances have shown potential in promoting wound healing, anti-aging, skin hydration, anti-tyrosinase activity, and hair dyeing. These benefits have been evaluated in various in vitro and in vivo studies. The therapeutic potential of J. regia suggests that its components could be integrated into treatment protocols and skincare routines. However, to optimize effectiveness and safety, future research should focus on in vivo studies in human subjects to determine the ideal concentrations and formulations of J. regia active compounds for specific skin conditions.
