Progress in Organ Bioprinting for Regenerative Medicine
Xiang Wang,
Di Zhang,
Yogendra Pratap Singh,
Miji Yeo,
Guotao Deng,
Jiaqi Lai,
Fei Chen,
Ibrahim T. Ozbolat,
Yin Yu
Affiliations
Xiang Wang
Center for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Di Zhang
Center for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Yogendra Pratap Singh
The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA; Engineering Science and Mechanics Department, Pennsylvania State University, University Park, PA 16802, USA
Miji Yeo
The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA; Engineering Science and Mechanics Department, Pennsylvania State University, University Park, PA 16802, USA
Guotao Deng
Center for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Jiaqi Lai
Center for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Fei Chen
Center for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Corresponding authors.
Ibrahim T. Ozbolat
The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA; Engineering Science and Mechanics Department, Pennsylvania State University, University Park, PA 16802, USA; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA; Materials Research Institute, Pennsylvania State University, University Park, PA 16802, USA; Department of Neurosurgery, Pennsylvania State College of Medicine, Hershey 17033, PA, USA; Pennsylvania State Cancer Institute, Pennsylvania State University, University Park, PA 16802, USA; Biotechnology Research and Application Center, Cukurova University, Adana 01130, Türkiye; Corresponding authors.
Yin Yu
Center for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Corresponding authors.
Organ damage or failure arising from injury, disease, and aging poses challenges due to the body’s limited regenerative capabilities. Organ transplantation presents the issues of donor shortages and immune rejection risks, necessitating innovative solutions. The three-dimensional (3D) bioprinting of organs on demand offers promise in tissue engineering and regenerative medicine. In this review, we explore the state-of-the-art bioprinting technologies, with a focus on bioink and cell type selections. We follow with discussions on advances in the bioprinting of solid organs, such as the heart, liver, kidney, and pancreas, highlighting the importance of vascularization and cell integration. Finally, we provide insights into key challenges and future directions in the context of the clinical translation of bioprinted organs and their large-scale production.
