Nature Communications (Jun 2016)
MAIT cells are activated during human viral infections
- Bonnie van Wilgenburg,
- Iris Scherwitzl,
- Edward C. Hutchinson,
- Tianqi Leng,
- Ayako Kurioka,
- Corinna Kulicke,
- Catherine de Lara,
- Suzanne Cole,
- Sirijitt Vasanawathana,
- Wannee Limpitikul,
- Prida Malasit,
- Duncan Young,
- Laura Denney,
- STOP-HCV consortium,
- Michael D. Moore,
- Paolo Fabris,
- Maria Teresa Giordani,
- Ye Htun Oo,
- Stephen M. Laidlaw,
- Lynn B. Dustin,
- Ling-Pei Ho,
- Fiona M. Thompson,
- Narayan Ramamurthy,
- Juthathip Mongkolsapaya,
- Christian B. Willberg,
- Gavin R. Screaton,
- Paul Klenerman
Affiliations
- Bonnie van Wilgenburg
- Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, University of Oxford
- Iris Scherwitzl
- Division of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Imperial College
- Edward C. Hutchinson
- Sir William Dunn School of Pathology, University of Oxford, University of Oxford
- Tianqi Leng
- Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, University of Oxford
- Ayako Kurioka
- Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, University of Oxford
- Corinna Kulicke
- Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, University of Oxford
- Catherine de Lara
- Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, University of Oxford
- Suzanne Cole
- Nuffield Department of Clinical Medicine, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
- Sirijitt Vasanawathana
- Department of Pediatric, Khon Kaen Hospital
- Wannee Limpitikul
- Department of Pediatric, Songkhla Hospital
- Prida Malasit
- BIOTEC, NSTDA
- Duncan Young
- Nuffield Department of Anesthesia, The John Radcliffe Hospital
- Laura Denney
- Nuffield Department of Clinical Medicine, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
- STOP-HCV consortium
- Michael D. Moore
- Sir William Dunn School of Pathology, University of Oxford, University of Oxford
- Paolo Fabris
- Infectious Diseases and Tropical Medicine Unit, San Bortolo Hospital
- Maria Teresa Giordani
- Infectious Diseases and Tropical Medicine Unit, San Bortolo Hospital
- Ye Htun Oo
- Centre for Liver Research & NIHR Biomedical Research Unit in Liver Disease, University of Birmingham
- Stephen M. Laidlaw
- Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford
- Lynn B. Dustin
- Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford
- Ling-Pei Ho
- Nuffield Department of Clinical Medicine, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
- Fiona M. Thompson
- Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, University of Oxford
- Narayan Ramamurthy
- Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, University of Oxford
- Juthathip Mongkolsapaya
- Division of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Imperial College
- Christian B. Willberg
- Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, University of Oxford
- Gavin R. Screaton
- Division of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Imperial College
- Paul Klenerman
- Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, University of Oxford
- DOI
- https://doi.org/10.1038/ncomms11653
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
Mucosal Associated Invariant T cells have been implicated in response to bacterial pathogens. Here the authors show that in human viral infections, these cells are activated by IL-18 in cooperation with other pro-inflammatory cytokines, producing interferon gamma and granzyme B.
