Nature Communications (Dec 2016)

Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction

  • Anthony C. Cruz,
  • Madhu Ramaswamy,
  • Claudia Ouyang,
  • Christopher A. Klebanoff,
  • Prabuddha Sengupta,
  • Tori N. Yamamoto,
  • Françoise Meylan,
  • Stacy K. Thomas,
  • Nathan Richoz,
  • Robert Eil,
  • Susan Price,
  • Rafael Casellas,
  • V. Koneti Rao,
  • Jennifer Lippincott-Schwartz,
  • Nicholas P. Restifo,
  • Richard M. Siegel

DOI
https://doi.org/10.1038/ncomms13895
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

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Fas drives apoptosis and mutations in this receptor can cause autoimmunity through failure of cell death. Here, the authors uselpr/lprmice with palmitoylation-defective mutant Fas to provide evidence that Fas might limit spontaneous autoimmunity through a non-apoptotic mechanism.